Concepedia

Mapping Conformational Dynamics to Individual Steps in the TEM-1 β-Lactamase Catalytic Mechanism

Ruth Knox, Cristina Lento, Derek J. Wilson

Journal of Molecular Biology · 2018 · 33 citations · 64 references

DOI

Concepts

References

64

The structure of β-lactamases

R P Ambler · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1980 · 1.8K citations

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Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

Justin B. Siegel, Alexandre Zanghellini, Helena M. Lovick et al. · Science · 2010 · 927 citations

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Allosteric inhibition of protein tyrosine phosphatase 1B

Christian Wiesmann, Kenneth J. Barr, Jenny Kung et al. · Nature Structural & Molecular Biology · 2004 · 530 citations

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Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

David E. Ehmann, Haris Jahić, Philip L. Ross et al. · Proceedings of the National Academy of Sciences · 2012 · 527 citations · Full text

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Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution

N.C.J. Strynadka, Hiroyuki Adachi, Susan E. Jensen et al. · Nature · 1992 · 526 citations

, , +15