Enzyme Conformational Dynamics is a biophysical framework that characterizes the time-dependent structural fluctuations and functional transitions of enzyme molecules, distinguishing it from static structural models by emphasizing the dynamic interplay between conformational states and catalytic activity.
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2017–2026
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Single-Molecule Enzymatic Dynamics
H. Peter Lu · 1998 · 1.5K citations
Intrinsic dynamics of an enzyme underlies catalysis
Elan Eisenmesser, Óscar Millet, Wladimir Labeikovsky et al. · Nature · 2005 · 1.1K citations
A hierarchy of timescales in protein dynamics is linked to enzyme catalysis
Katherine A. Henzler‐Wildman, Ming Lei, Vu Thai et al. · Nature · 2007 · 1.1K citations
The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis
David D. Boehr, Dan McElheny, H. Jane Dyson et al. · Science · 2006 · 961 citations
Enzyme Dynamics During Catalysis
Elan Eisenmesser, Daryl A. Bosco, Mikael Akke et al. · Science · 2002 · 728 citations · Full text
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- PE
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- JA
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- HJ
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- TCThomas C. Bruice
University of California, Santa Barbara, United States
13 publications · 496 citations
12
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- AJ
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Howard Hughes Medical Institute
Chevy Chase, United States
26 h-index
74 publications
18.6K citations
Centre National de la Recherche Scientifique
Paris, France
26 h-index
206 publications
7.7K citations
Harvard University
Cambridge, United States
24 h-index
71 publications
5.8K citations
Scripps Research Institute
San Diego, United States
22 h-index
89 publications
16.7K citations
National Institutes of Health
Bethesda, United States
20 h-index
84 publications
7.4K citations
Université Grenoble Alpes
Saint-Martin-d'Hères, France
19 h-index
82 publications
3.8K citations
Stanford University
Stanford, United States
19 h-index
70 publications
4.9K citations
Institut de Biologie Structurale
Grenoble, France
19 h-index
79 publications
3.8K citations
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- Proceedings of the National Academy of Sciences
PNAS · 98 publications · 10K citations
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- Journal of the American Chemical Society
JACS · 77 publications · 4.5K citations
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- Biochemistry
145 publications · 5.7K citations
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- Journal of Molecular Biology
JMB · 53 publications · 3.2K citations
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- Journal of Biological Chemistry
JBC · 75 publications · 2.4K citations
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