David D. Boehr

The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis

David D. Boehr, Dan McElheny, H. Jane Dyson et al. · Science · 2006 · 953 citations

Maximum Hydride Transfer, Biochemistry, Dynamic Energy Landscape +15

Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands

David D. Boehr, Dan McElheny, H. Jane Dyson et al. · Proceedings of the National Academy of Sciences · 2010 · 143 citations · Full text

Protein Chemistry, Protein Assembly, Biochemistry +15

Design of Bifunctional Antibiotics that Target Bacterial rRNA and Inhibit Resistance-Causing Enzymes

Steven J. Sucheck, Andrew L. Wong, Kathryn M. Koeller et al. · Journal of the American Chemical Society · 2000 · 137 citations

Bifunctional Antibiotics, Altmetric Attention Score, Antimicrobial Chemotherapy +21

The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

Lonneke van der Linden, Laia Vives-Adrián, Barbara Selisko et al. · PLoS Pathogens · 2015 · 97 citations · Full text

Multiple Genera, Crystal Structure, Viral Replication +21

Analysis of the π-π Stacking Interactions between the Aminoglycoside Antibiotic Kinase APH(3′)-IIIa and Its Nucleotide Ligands

David D. Boehr, Adam R. Farley, Gerard D. Wright et al. · Chemistry & Biology · 2002 · 95 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +13