Concepedia

Conformational Activation

Conformational Activation is a biochemical mechanism whereby an enzyme undergoes a structural rearrangement into an active conformation, enabling catalytic function through the precise alignment of active site residues.

340

Publications

18.7K

Citations

1.6K

Authors

498

Institutions

Publications per year

2017–2026

70

Parents

Publications

340

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

David M. Duda, Laura A. Borg, Daniel C. Scott et al. · Cell · 2008 · 765 citations

, , +7

Conformation change of cytochrome c

Tsunehiro Takano, Richard E. Dickerson · Journal of Molecular Biology · 1981 · 563 citations

, , +14

Activation of Pheromone-Sensitive Neurons Is Mediated by Conformational Activation of Pheromone-Binding Protein

John D. Laughlin, Tal Soo Ha, David N. M. Jones et al. · Cell · 2008 · 452 citations · Full text

, , +16

Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

Daniel M. Pinkas, Pavel Strop, Axel T. Brünger et al. · PLoS Biology · 2007 · 445 citations · Full text

, , +16

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

Bruno Fiévet, Alexis Gautreau, Christian Roy et al. · The Journal of Cell Biology · 2004 · 381 citations · Full text

, , +13

1–5 of 340

Authors

1.6K

  1. ST
    Steven T. Olson

    University of Illinois Chicago, United States

    7 publications · 260 citations

    7

    h-index

  2. PB
    Paul Bock

    Vanderbilt University, United States

    7 publications · 360 citations

    7

    h-index

  3. UR
    Umesh R. Desai

    Virginia Commonwealth University, United States

    5 publications · 208 citations

    5

    h-index

  4. PP
    Peter Panizzi

    Auburn University, United States

    4 publications · 214 citations

    4

    h-index

  5. GI
    Gonzalo Izaguirre

    University of Illinois Chicago, United States

    4 publications · 146 citations

    4

    h-index

1–5 of 1.6K

Institutions

498

  1. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    51 publications

    4.4K citations

  2. University of Illinois Chicago

    Chicago, United States

    11 h-index

    37 publications

    1.5K citations

  3. KU Leuven

    Leuven, Belgium

    11 h-index

    44 publications

    2.2K citations

  4. Harvard University

    Cambridge, United States

    10 h-index

    27 publications

    1.6K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    14 publications

    3.9K citations

  6. Vanderbilt University

    Nashville, United States

    7 h-index

    20 publications

    959 citations

  7. Johns Hopkins University

    Baltimore, United States

    7 h-index

    23 publications

    757 citations

  8. Cornell University

    Ithaca, United States

    6 h-index

    16 publications

    544 citations

1–8 of 498

Venues

  1. Journal of Biological Chemistry

    JBC · 47 publications · 2.4K citations

    31

    h-index

  2. Biochemistry

    32 publications · 1.3K citations

    23

    h-index

  3. Journal of Molecular Biology

    JMB · 25 publications · 2.2K citations

    21

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 1.6K citations

    15

    h-index

  5. Nature Communications

    7 publications · 402 citations

    7

    h-index

1–5