Crystal Structure of <i>Escherichia coli</i> MscS, a Voltage-Modulated and Mechanosensitive Channel

Randal B. Bass, Pavel Strop, Margaret T. Barclay, +1

Science

Crystal StructureEngineeringBacteriologyMolecular BiologyMembrane Transport +15

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

Pavel Strop, Shu‐Hui Liu, Magdalena Dorywalska, +26

Chemistry & Biology

Location MattersDrug TargetingMedicineImmunologyAntibody Screening +8

Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

Daniel M. Pinkas, Pavel Strop, Axel T. Brünger, +1

PLoS Biology

Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1β Complex Reveal Specific Protein-Protein and Protein-Ca2+ Interactions

Demet Araç, Antony A. Boucard, Engin Özkan, +4

Neuron

Protein FunctionBiochemistryNatural SciencesSynaptic TransmissionMolecular Biology +4

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Magdalena Dorywalska, Russell G. Dushin, Ludivine Moine, +15

Molecular Cancer Therapeutics

Molecular BiologyChemical BiologyAntibody EngineeringAnti-cancer AgentValine-citrulline-pabc Linker Instability +16

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

Ucheor B. Choi, Pavel Strop, Marija Vrljic, +3

Nature Structural & Molecular Biology

Biophysical ModelingFusion ComplexMolecular BiologyMembrane BiologyMedicine +1

Fabs Enable Single Particle cryoEM Studies of Small Proteins

Shenping Wu, Agustin Avila-Sakar, Jung‐Min Kim, +17

Structure

Natural SciencesSingle Particle BiophysicsMolecular BiologyProtein RefoldingProteomics +2

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

Yasmina Abdiche, Yik A. Yeung, Javier Chaparro‐Riggers, +9

mAbs

ImmunologyImmune RegulationInnate ImmunityImmune SystemImmunotherapy +22

Refractive index‐based determination of detergent concentration and its application to the study of membrane proteins

Pavel Strop, Axel T. Brünger

Protein Science

Refractive Index‐based DeterminationBiochemistryNatural SciencesDetergent ConcentrationBioanalysis +11

Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9

Javier Chaparro‐Riggers, Liang Hong, Rachel M. DeVay, +16

Journal of Biological Chemistry