Concepedia

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

Pavel Strop, Shu‐Hui Liu, Magdalena Dorywalska, Kathy Delaria, Russell G. Dushin, Thomas-Toan Tran, Wei-Hsien Ho, Santiago Farias, Meritxell Galindo Casas, Yasmina Abdiche,

Chemistry & Biology · 2013 · 498 citations · 16 references

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16

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.4K citations

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Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

Kevin J. Hamblett, Peter D. Senter, Dana F. Chace et al. · Clinical Cancer Research · 2004 · 1.2K citations

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Ben‐Quan Shen, Keyang Xu, Luna Liu et al. · Nature Biotechnology · 2012 · 999 citations

, , +17

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

Peter D. Senter, Eric L. Sievers · Nature Biotechnology · 2012 · 752 citations

, , +15

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

Jun Y. Axup, Krishna Bajjuri, Melissa Ritland et al. · Proceedings of the National Academy of Sciences · 2012 · 582 citations · Full text

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