Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

Pavel Strop, Shu‐Hui Liu, Magdalena Dorywalska, +26

Chemistry & Biology

Location MattersDrug TargetingMedicineImmunologyAntibody Screening +8

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Magdalena Dorywalska, Russell G. Dushin, Ludivine Moine, +15

Molecular Cancer Therapeutics

Molecular BiologyChemical BiologyAntibody EngineeringAnti-cancer AgentValine-citrulline-pabc Linker Instability +16

Effect of Attachment Site on Stability of Cleavable Antibody Drug Conjugates

Magdalena Dorywalska, Pavel Strop, Jody A. Melton-Witt, +18

Bioconjugate Chemistry

RN927C, a Site-Specific Trop-2 Antibody–Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models

Pavel Strop, Thomas-Toan Tran, Magdalena Dorywalska, +14

Molecular Cancer Therapeutics

Mass Spectrometric Characterization of Transglutaminase Based Site-Specific Antibody–Drug Conjugates

Santiago Farias, Pavel Strop, Kathy Delaria, +5

Bioconjugate Chemistry

ImmunologyBiological Mass SpectrometryChemical Conjugation MethodsChemical BiologyTumor Biology +17

Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy

Magdalena Dorywalska, Pavel Strop, Jody A. Melton-Witt, +18

PLoS ONE

Rodent PlasmaImmunocytochemical TechniqueMedicineSite-dependent DegradationConjugation Sites +10

Improved Lysosomal Trafficking Can Modulate the Potency of Antibody Drug Conjugates

Rachel M. DeVay, Kathy Delaria, Guoyun Zhu, +12

Bioconjugate Chemistry

Immunocytochemical TechniqueEngineeringLysosomal Storage DiseaseImmunologyImmunotherapeutics +21

Comparison of competitive ligand-binding assay and bioassay formats for the measurement of neutralizing antibodies to protein therapeutics

Deborah Finco, Daniel Baltrukonis, Adrienne Clements‐Egan, +5

Journal of Pharmaceutical and Biomedical Analysis

Competitive Ligand-binding AssayMedicineNatural SciencesBioanalysisImmunology +10

Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Siler H. Panowski, Tracy C. Kuo, Yi Zhang, +27

Molecular Cancer Therapeutics

Three-dimensional models of the GDP and GTP forms of the guanine nucleotide domain of Escherichia coli elongation factor Tu

Frances Jurnak, Susan Heffron, Brian Schick, +1

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Three-dimensional ModelsStructural BioinformaticsBiomolecular Structure PredictionComputational BiologyMolecular Biology +5