Thomas-Toan Tran

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

Pavel Strop, Shu‐Hui Liu, Magdalena Dorywalska et al. · Chemistry & Biology · 2013 · 486 citations

Location Matters, Drug Targeting, Medicine +10

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Magdalena Dorywalska, Russell G. Dushin, Ludivine Moine et al. · Molecular Cancer Therapeutics · 2016 · 199 citations

Molecular Biology, Chemical Biology, Antibody Engineering +18

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling

Wendy J. Ingram, Karen McCue, Thomas-Toan Tran et al. · Oncogene · 2007 · 170 citations

Novel Mechanism, Signal Transduction, Developmental Biology +9

Effect of Attachment Site on Stability of Cleavable Antibody Drug Conjugates

Magdalena Dorywalska, Pavel Strop, Jody A. Melton-Witt et al. · Bioconjugate Chemistry · 2015 · 147 citations

RN927C, a Site-Specific Trop-2 Antibody–Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models

Pavel Strop, Thomas-Toan Tran, Magdalena Dorywalska et al. · Molecular Cancer Therapeutics · 2016 · 98 citations