Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

David E. Ehmann, Haris Jahić, Philip L. Ross, +5

Proceedings of the National Academy of Sciences

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

David E. Ehmann, Haris Jahić, Philip L. Ross, +10

Journal of Biological Chemistry

D β-LactamasesAntimicrobial ChemotherapyAvibactam InhibitionDrug ResistanceAntimicrobial Therapy +14

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii

Thomas F. Durand-Réville, Satenig Guler, Janelle Comita-Prevoir, +23

Nature Microbiology

Bacterial ResistanceAntimicrobial SusceptibilityHealth SciencesAntibioticsMedicine +10

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

William F. Penwell, Adam B. Shapiro, R.A. Giacobbe, +8

Antimicrobial Agents and Chemotherapy

Antibacterial ActivityPenicillin-binding ProteinsSulbactam Antibacterial ActivityAntibiotic ResistanceBacterial Pathogens +18

Lysine Biosynthesis in <i>Saccharomyces cerevisiae:  </i>Mechanism of α-Aminoadipate Reductase (Lys2) Involves Posttranslational Phosphopantetheinylation by Lys5

David E. Ehmann, Amy M. Gehring, Christopher T. Walsh

Biochemistry

Translating slow-binding inhibition kinetics into cellular and in vivo effects

Grant K. Walkup, Zhiping You, Philip L. Ross, +17

Nature Chemical Biology

Signal TransductionBiochemistryCell SignalingMedicineNatural Sciences +11

Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases

David E. Ehmann, John W. Trauger, Torsten Stachelhaus, +1

Chemistry & Biology

Nonribosomal Peptide SynthetasesSmall-molecule SubstratesBiochemistryProtein FoldingNatural Sciences +6

The EntF and EntE adenylation domains of <i>Escherichia coli</i> enterobactin synthetase: Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates

David E. Ehmann, Cathryn A. Shaw-Reid, Heather C. Losey, +1

Proceedings of the National Academy of Sciences

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity

Folkert Reck, Richard A. Alm, Patrick Brassil, +16

Journal of Medicinal Chemistry

Reduced Herg ActivityAntimicrobial ChemotherapyPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +19

Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48

Sushmita D. Lahiri, Stefano Mangani, Haris Jahić, +7

ACS Chemical Biology

Antimicrobial ChemotherapyClass DStructure-guided StudyAntibiotic ResistanceBacterial Pathogens +20