Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

David E. Ehmann, Haris Jahić, Philip L. Ross, +5

Proceedings of the National Academy of Sciences

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

David E. Ehmann, Haris Jahić, Philip L. Ross, +10

Journal of Biological Chemistry

D β-LactamasesAntimicrobial ChemotherapyAvibactam InhibitionDrug ResistanceAntimicrobial Therapy +14

Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48

Sushmita D. Lahiri, Stefano Mangani, Haris Jahić, +7

ACS Chemical Biology

Antimicrobial ChemotherapyClass DStructure-guided StudyAntibiotic ResistanceBacterial Pathogens +20

Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514

Adam B. Shapiro, Ning Gao, Haris Jahić, +3

ACS Infectious Diseases

Bioorganic ChemistryAntimicrobial ChemotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +19

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with <i>MTAP</i>-Deleted Cancers

Kevin M. Cottrell, Kimberly J. Briggs, Douglas A. Whittington, +15

Journal of Medicinal Chemistry

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation

Michael J. Thomenius, Jennifer Totman, Darren M. Harvey, +31

PLoS ONE

Small Molecule InhibitorsEngineeringMolecular BiologySpecific Target MacromoleculesTumor Biology +17

A Homogeneous, High-Throughput Fluorescence Anisotropy-Based DNA Supercoiling Assay

Adam B. Shapiro, Haris Jahić, Swati Prasad, +4

SLAS DISCOVERY

Biomolecular ToolDna AnalysisMolecular BiologyBioanalysisPlasmid Dna +14

SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of <i>Pseudomonas aeruginosa</i> PBP3

Kerry E. Murphy-Benenato, Brian Dangel, Hajnalka E. Davis, +13

ACS Medicinal Chemistry Letters

New AgentsTarget PenicillinAntimicrobial ChemotherapyAnalytical UltracentrifugationChemical Biology +19

A High-Throughput, Homogeneous, Fluorescence Resonance Energy Transfer-Based Assay for Phospho-N-acetylmuramoyl-pentapeptide Translocase (MraY)

Adam B. Shapiro, Haris Jahić, Ning Gao, +2

SLAS DISCOVERY

Peptidoglycan BiosynthesisBiochemistryNovel Mray InhibitorsMedicineNatural Sciences +13

Discovery of Efficacious <i>Pseudomonas aeruginosa</i>-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model

Kerry E. Murphy-Benenato, Pratik Bhagunde, April Chen, +23

Journal of Medicinal Chemistry

Lead CompoundsNew AgentsAntimicrobial ChemotherapyPharmacodynamic ModelingDrug Resistance +19