Stefano Mangani

A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: why urea hydrolysis costs two nickels

Stefano Benini, W. Rypniewski, Keith S. Wilson et al. · Structure · 1999 · 500 citations · Full text

Life Sciences, Biochemistry, Microbiology +13

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Bin Liu, Robert E. Lee Trout, Guo‐Hua Chu et al. · Journal of Medicinal Chemistry · 2019 · 298 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Carbonic Anhydrase Activators:  X-ray Crystallographic and Spectroscopic Investigations for the Interaction of Isozymes I and II with Histamine^,

Fabrizio Briganti, Stefano Mangani, Pierluigi Orioli et al. · Biochemistry · 1997 · 270 citations

Life Sciences, Biochemistry, Chemistry +17

Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-Lactamases

Sushmita D. Lahiri, Stefano Mangani, Thomas F. Durand-Réville et al. · Antimicrobial Agents and Chemotherapy · 2013 · 221 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in <i>Enterobacterales</i> and Pseudomonas aeruginosa

Jodie C. Hamrick, Jean‐Denis Docquier, Tsuyoshi Uehara et al. · Antimicrobial Agents and Chemotherapy · 2019 · 213 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17