Kevin M. Cottrell

In Vitro Resistance Studies of Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061

Chao Lin, Kai Lin, Yu-Ping Luong et al. · Journal of Biological Chemistry · 2004 · 289 citations · Full text

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with <i>MTAP</i>-Deleted Cancers

Kevin M. Cottrell, Kimberly J. Briggs, Douglas A. Whittington et al. · Journal of Medicinal Chemistry · 2024 · 58 citations · Full text

Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants

Robert B. Perni, Luc J. Farmer, Kevin M. Cottrell et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 52 citations · Full text

Viral Hepatitis, Antiviral Drug Development, Antiviral Therapy +9

Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase γ

Philip N. Collier, Gabriel Martínez-Botella, Mark Cornebise et al. · Journal of Medicinal Chemistry · 2014 · 51 citations · Full text

Drug Target, Molecular Biology, Molecular Pharmacology +18

Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases

Philip D. Edwards, Russell C. Mauger, Kevin M. Cottrell et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 38 citations

Protease Inhibitors, Protein Chemistry, Biochemistry +11