Kevin M. Cottrell

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with <i>MTAP</i>-Deleted Cancers

Kevin M. Cottrell, Kimberly J. Briggs, Douglas A. Whittington et al. · Journal of Medicinal Chemistry · 2024 · 67 citations · Full text

Medicine, Oncology, Pharmacology +13

Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants

Robert B. Perni, Luc J. Farmer, Kevin M. Cottrell et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 53 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase γ

Philip N. Collier, Gabriel Martínez-Botella, Mark Cornebise et al. · Journal of Medicinal Chemistry · 2014 · 52 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases

Philip D. Edwards, Russell C. Mauger, Kevin M. Cottrell et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 38 citations

Life Sciences, Biochemistry, Medicinal Chemistry +13

Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ

Philip N. Collier, David Messersmith, Arnaud LeTiran et al. · Journal of Medicinal Chemistry · 2015 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15