Douglas A. Whittington

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 677 citations · Full text

Drug Target, Solid Tumors, Molecular Biology +20

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Sean Caenepeel, Sean P. Brown, Brian Belmontes et al. · Cancer Discovery · 2018 · 408 citations · Full text

Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase

Douglas A. Whittington, Mitchell L. Wise, Marek Urbanský et al. · Proceedings of the National Academy of Sciences · 2002 · 319 citations · Full text

Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells

Douglas A. Whittington, Abdül Waheed, Barbara Ulmasov et al. · Proceedings of the National Academy of Sciences · 2001 · 319 citations · Full text

Crystal Structure, Proteinlipid Interaction, Protein Assembly +18

2.4 Å Crystal Structure of an Oxaliplatin 1,2-d(GpG) Intrastrand Cross-Link in a DNA Dodecamer Duplex

Bernhard Spingler, Douglas A. Whittington, Stephen J. Lippard · Inorganic Chemistry · 2001 · 206 citations