High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Cole Trapnell, Brian A. Williams, Geo Pertea et al. · Nature Biotechnology · 2010 · 16.5K citations

Life Sciences, Cell Biology, Molecular Biology +16

TopHat: discovering splice junctions with RNA-Seq

Cole Trapnell, Lior Pachter, Steven L. Salzberg · Bioinformatics · 2009 · 12.1K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +16

Functional profiling of the Saccharomyces cerevisiae genome

Guri Giaever, Angela Chu, Li Ni et al. · Nature · 2002 · 4.5K citations

Life Sciences, Genetics, Molecular Biology +13

Multifunctional yeast high-copy-number shuttle vectors

Thomas Christianson, Robert Sikorski, Michael Dante et al. · Gene · 1992 · 1.7K citations

Agriculture, Molecular Biology, Molecular Genetics +7

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

Benjamin P. Kleinstiver, Michelle S. Prew, Shengdar Q. Tsai et al. · Nature · 2015 · 1.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +13