CLICK: one-step generation of conditional knockout mice

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

Haoyi Wang, Hui Yang, Chikdu Shivalila et al. · Cell · 2013 · 3.5K citations · Full text

Off-target Effect, Engineering, Genome Surgery +12

A conditional knockout resource for the genome-wide study of mouse gene function

William C. Skarnes, Barry P. Rosen, Anthony P. West et al. · Nature · 2011 · 1.8K citations · Full text

Knockout Mouse, Functional Genomics, Genetics +13

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

Hui Yang, Haoyi Wang, Chikdu Shivalila et al. · Cell · 2013 · 1.6K citations · Full text

Knockout Mouse, Engineering, Genome Surgery +13

A Mutation in the Vesicle-Trafficking Protein VAPB Causes Late-Onset Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis

Agnes L. Nishimura, Miguel Mitne‐Neto, Helga Cristina Almeida da Silva et al. · The American Journal of Human Genetics · 2004 · 970 citations · Full text

Neurodegenerative Diseases, Protein Function, Amyotrophic Lateral Sclerosis +6

Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice

Huanbin Zhou, Bo Liu, Donald P. Weeks et al. · Nucleic Acids Research · 2014 · 606 citations · Full text

Genetics, Multiplex Gene, Molecular Biology +17