Cell · 2013 · 1.6K citations · 23 references
Life SciencesGeneticsMolecular GeneticsGenetic EngineeringGenome EditingGenome EngineeringAnimal Genetic EngineeringConditional Transgenic ModelsCrispr-based EngineeringCrispr-cas SystemsGene Knockout StrategiesTransgenic Organism ProductionConditional Knock-in AllelesConditional Lethal AllelesCrispr-based Genome EngineeringCrispr-cas Genome EditingCrispr-cas9 Knockout Models
23
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.7K citations
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.4K citations · Full text
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Lei S. Qi, Matthew H. Larson, Luke A. Gilbert et al. · Cell · 2013 · 5.2K citations · Full text
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu, David A. Scott, Joshua A. Weinstein et al. · Nature Biotechnology · 2013 · 4.9K citations · Full text