Concepedia

Conditional Gene Knockout

A Conditional Gene Knockout is a genetic engineering technique that enables the targeted inactivation of a specific gene in a spatially or temporally controlled manner within a subset of cells or tissues, distinguishing it from conventional knockouts by its dependence on external inducers or tissue-specific promoters to achieve precise spatiotemporal regulation of gene function loss.

1.1K

Publications

86K

Citations

8.2K

Authors

1.6K

Institutions

Publications per year

2017–2026

417

Variants

Conditional Knockout

Parents

Publications

1.1K

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

Georg Dietzl, Doris Chen, Frank Schnorrer et al. · Nature · 2007 · 2.8K citations

, , +14

Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice

Masaaki Komatsu, Satoshi Waguri, Takashi Ueno et al. · The Journal of Cell Biology · 2005 · 2.3K citations · Full text

, , +15

Conditional gene targeting in macrophages and granulocytes using LysMcre mice

Björn E. Clausen, Christoph Burkhardt, Walter Reith et al. · Transgenic Research · 1999 · 2.2K citations

, , +10

A conditional knockout resource for the genome-wide study of mouse gene function

William C. Skarnes, Barry P. Rosen, Anthony P. West et al. · Nature · 2011 · 1.8K citations

, , +16

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

Kevin K. Park, Kai Liu, Yang Hu et al. · Science · 2008 · 1.7K citations · Full text

, , +16

1–5 of 1.1K

Authors

8.2K

  1. CD
    Chu‐Xia Deng

    National Institutes of Health, United States

    9 publications · 974 citations

    9

    h-index

  2. KH
    Klaus H. Kaestner

    University of Pennsylvania, United States

    8 publications · 1.3K citations

    8

    h-index

  3. MM
    Martin M. Matzuk

    Baylor College of Medicine, United States

    8 publications · 829 citations

    8

    h-index

  4. KW
    Kay‐Uwe Wagner

    University of Nebraska Medical Center, United States

    7 publications · 381 citations

    7

    h-index

  5. JP
    John P. Lydon

    Baylor College of Medicine, United States

    6 publications · 378 citations

    6

    h-index

1–5 of 8.2K

Institutions

1.6K

  1. Harvard University

    Cambridge, United States

    33 h-index

    148 publications

    14.3K citations

  2. Baylor College of Medicine

    Houston, United States

    31 h-index

    159 publications

    11.7K citations

  3. National Institutes of Health

    Bethesda, United States

    31 h-index

    133 publications

    16.1K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    26 h-index

    88 publications

    14.8K citations

  5. Johns Hopkins University

    Baltimore, United States

    23 h-index

    132 publications

    12.5K citations

  6. Chinese Academy of Sciences

    Beijing, China

    23 h-index

    206 publications

    19.5K citations

  7. Kyoto University

    Kyoto, Japan

    23 h-index

    103 publications

    7.1K citations

  8. Washington University in St. Louis

    St Louis, United States

    22 h-index

    117 publications

    7.2K citations

1–8 of 1.6K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 52 publications · 8.4K citations

    41

    h-index

  2. Nature Communications

    39 publications · 3.1K citations

    34

    h-index

  3. genesis

    46 publications · 2.4K citations

    29

    h-index

  4. PLoS ONE

    63 publications · 2.4K citations

    28

    h-index

  5. The Journal of Immunology

    JI · 37 publications · 3.2K citations

    27

    h-index

1–5