Concepedia

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

Lianfeng Wu, Ben Zhou, Noriko Oshiro-Rapley, Man Li, João A. Paulo, Christopher M. Webster, Fan Mou, Michael C. Kacergis, Michael E. Talkowski, Christopher E. Carr,

Cell · 2016 · 230 citations · 43 references

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43

THE GENETICS OF <i>CAENORHABDITIS ELEGANS</i>

Sydney Brenner · Genetics · 1974 · 15.5K citations · Full text

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Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.4K citations

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Yasemin Sancak, Timothy R. Peterson, Yoav D. Shaul et al. · Science · 2008 · 2.8K citations

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Metformin and reduced risk of cancer in diabetic patients

Josie Evans, Louise A. Donnelly, Alistair Emslie‐Smith et al. · BMJ · 2005 · 2.4K citations · Full text

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

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