Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap

Biochemical Journal

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap

Biochemical Journal

Anti-diabetic EffectsMitochondrial OxidationMetabolic RemodelingInsulin SignalingOxidative Stress +20

Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes

E. Doran, F.W. Whittington, J.D. Wood, +1

Chemico-Biological Interactions

Molecular PharmacologyCytochrome P450iie1OxysterolBiochemistryMedicine +9

Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites

E. Doran, Andrew P. Halestrap

Biochemical Journal

Mitochondrial SuspensionsExperimental PharmacologyRedox BiologyCellular PhysiologyOxidative Stress +15

Characterisation of androstenone metabolism in pig liver microsomes

E. Doran, Frances M. Whittington, J.D. Wood, +1

Chemico-Biological Interactions

BiochemistryLiver PhysiologyPhysiologyHepatotoxicityMetabolism +6

Relationships between skatole and androstenone accumulation, and cytochrome P4502E1 expression in Meishan×Large White pigs

FM Whittington, G.R. Nute, S.I. Hughes, +4

Meat Science

BiologyAnimal PhysiologyComparative EndocrinologyMedicineMammalian Physiology +9

The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone

Winston S. Tambyrajah, E. Doran, J.D. Wood, +1

Archives of Biochemistry and Biophysics

Transcriptional RegulationSignal TransductionMolecular PhysiologySignaling PathwayCell Regulation +10

Cloning and mapping of the porcine <i>cytochrome‐p450 2E1</i> gene and its association with skatole levels in the domestic pig

T.M. Skinner, E. Doran, J D McGivan, +2

Animal Genetics

The relationship between adipose tissue skatole levels, rates of hepatic microsomal skatole metabolism and hepatic cytochrome P450IIE1 expression in two breeds of pig

E. Doran, F.W. Whittington, J.D. Wood, +1

Animal Science

ToxicologyHepatotoxicityMetabolic SignalingMetabolic StateHealth Sciences +16

Mitochondria and cell death: a pore way to die?

Andrew P. Halestrap, J P Gillespie, A. O’Toole, +1

PubMed

Mitochondrial FunctionLongevityPhysiologyMitochondrial DynamicsCell Death +4