Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

Hong Lu, Lianfeng Wu, Leping Liu, +6

Biochemical Pharmacology

InflammationKidney InjuryTranslational MedicineFibrosisM1/m2 Macrophage Polarization +12

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

Lianfeng Wu, Ben Zhou, Noriko Oshiro-Rapley, +10

Cell

Metformin Growth InhibitionSignal TransductionSignaling PathwayAutophagyC. Elegans +6

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

Ben Zhou, Johannes Kreuzer, Caroline Kumsta, +13

Cell

Lifespan ExtensionCell AutophagyMitophagyMitochondrial FunctionLongevity +6

COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential

Yujie Jiang, Xin Wei, Jingjing Guan, +8

Clinical Immunology

Cd8+ TMedicineImmunologyImmunologic MechanismT Cell Immunity +7

Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern

Runshuai Zhang, Yuanzhen He, Luxia Yao, +9

Environment International

Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans

Shenlu Qin, Yihan Wang, Lili Li, +12

Cell Reports

GeneticsLipid PeroxidationRedox BiologyOxidative StressMetabolic Syndrome +16

Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

Weixiang Bian, Mengfan Tang, Hua Jiang, +15

Developmental Cell

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Christopher M. Webster, Elizabeth C. Pino, Christopher E. Carr, +6

Cell Reports

Molecular RegulationGeneticsStarvation SurvivalMetabolic RemodelingProteostasis-ampk Axis +21

Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

Ben Zhou, Yuyao Zhang, Sainan Li, +4

Cell Reports

A non-canonical role for the <i>C. elegans</i> dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2

Christopher M. Webster, Lianfeng Wu, Denzil Douglas, +1

Development

Dpy-21 FunctionsMolecular RegulationMetabolic Regulation DownstreamGeneticsAltered Dcc +17