Impact of Ice Morphology on Design Space of Pharmaceutical Freeze-Drying

A new model for determining mean structure parameters of fixed beds from pressure drop measurements: application to beds packed with parallelepipedal particles

Jacques Comiti, Maurice Renaud · Chemical Engineering Science · 1989 · 524 citations

Engineering, Materials Science, Transport Phenomena +11

The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature‐controlled shelf

James A. Searles, John F. Carpenter, Theodore W. Randolph · Journal of Pharmaceutical Sciences · 2001 · 392 citations

Pharmacy, Biochemistry, Food Science +14

Heat and mass transfer scale-up issues during freeze drying: II. Control and characterization of the degree of supercooling

Shailaja Rambhatla, Roee Ramot, Chandan Bhugra et al. · AAPS PharmSciTech · 2004 · 239 citations · Full text

Pharmacy, Chemical Engineering, Materials Science +13

Development of simplified models for the freeze-drying process and investigation of the optimal operating conditions

Salvatore Velardi, Antonello Barresi · Process Safety and Environmental Protection · 2008 · 182 citations

Agriculture, Food Science, Food Engineering +15

Influence of controlled nucleation by ultrasounds on ice morphology of frozen formulations for pharmaceutical proteins freeze-drying

Kyuya Nakagawa, Aurélie Hottot, Séverine Vessot et al. · Chemical Engineering and Processing - Process Intensification · 2006 · 155 citations

Natural Sciences, Biochemistry, Food Science +16