Concepedia

Lyophilization Process Development

Lyophilization Process Development is a systematic optimization framework within pharmaceutical formulation science that integrates thermodynamic characterization, controlled freezing, primary drying, and secondary drying phases to design a robust and scalable freeze-drying protocol ensuring stability, solubility, and long-term viability of parenteral biologics.

211

Publications

9.1K

Citations

750

Authors

271

Institutions

Publications per year

2017–2026

71

Variants

Freeze-drying Process Development

Parents

Publications

211

Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilization

James A. Searles, John F. Carpenter, Theodore W. Randolph · Journal of Pharmaceutical Sciences · 2001 · 308 citations

, , +13

Lyophilization/Freeze Drying - An Review

Gr. Nireesha, Lakshmi S Divya, C. Sowmya et al. · International Journal of Novel Trends in Pharmaceutical Sciences · 2013 · 209 citations

, , +12

Use of subambient thermal analysis to optimize protein lyophilization

Byeong S. Chang, Cynthia S. Randall · Cryobiology · 1992 · 208 citations

, , +14

Stabilization of lipid/DNA complexes during the freezing step of the lyophilization process: the particle isolation hypothesis

Steven Allison, Marion d.C. Molina, Thomas J. Anchordoquy · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2000 · 175 citations

, , +15

Optimization of Lyophilization Conditions for Recombinant Human Interleukin-2 by Dried-State Conformational Analysis Using Fourier-Transform Infrared Spectroscopy

Steven J. Prestrelski, Katherine A. Pikal, Tsutomu Arakawa · Pharmaceutical Research · 1995 · 150 citations

, , +15

1–5 of 211

Authors

750

  1. AA
    Alina Alexeenko

    Purdue University West Lafayette, United States

    11 publications · 322 citations

    11

    h-index

  2. MJ
    Michael J. Pikal

    University of Connecticut, United States

    8 publications · 340 citations

    8

    h-index

  3. AB
    Antonello Barresi

    Politecnico di Torino, Italy

    8 publications · 589 citations

    8

    h-index

  4. DF
    Davide Fissore

    Politecnico di Torino, Italy

    7 publications · 427 citations

    7

    h-index

  5. ST
    Serguei Tchessalov

    Pfizer (United States), United States

    7 publications · 193 citations

    7

    h-index

1–5 of 750

Institutions

271

  1. Purdue University West Lafayette

    West Lafayette, United States

    14 h-index

    44 publications

    1K citations

  2. Politecnico di Torino

    Turin, Italy

    12 h-index

    38 publications

    2.4K citations

  3. University of Connecticut

    Storrs, United States

    10 h-index

    23 publications

    672 citations

  4. Pfizer (United States)

    New York, United States

    8 h-index

    22 publications

    781 citations

  5. Ludwig-Maximilians-Universität München

    Munich, Germany

    7 h-index

    14 publications

    607 citations

  6. Ghent University

    Ghent, Belgium

    6 h-index

    28 publications

    1.2K citations

  7. Baxter (United States)

    Deerfield, United States

    6 h-index

    15 publications

    287 citations

  8. AbbVie (United States)

    North Chicago, United States

    6 h-index

    20 publications

    700 citations

1–8 of 271

Venues

  1. Journal of Pharmaceutical Sciences

    37 publications · 1.9K citations

    25

    h-index

  2. International Journal of Pharmaceutics

    24 publications · 1.1K citations

    19

    h-index

  3. European Journal of Pharmaceutics and Biopharmaceutics

    EJPB · 13 publications · 646 citations

    12

    h-index

  4. Pharmaceutical Research

    11 publications · 608 citations

    11

    h-index

  5. Drying Technology

    7 publications · 388 citations

    7

    h-index

1–5