Michael J. Pikal

Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

Liuquan Chang, Deanna Shepherd, Joanna Sun et al. · Journal of Pharmaceutical Sciences · 2005 · 445 citations · Full text

Native Structure Preservation, Protein Chemistry, Biochemistry +8

Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis

Sharad B. Murdande, Michael J. Pikal, Ravi Shanker et al. · Journal of Pharmaceutical Sciences · 2009 · 382 citations

Engineering, Analytical Chemistry, Thermodynamics +5

Characterization of the Time Scales of Molecular Motion in Pharmaceutically Important Glasses

Sheri L. Shamblin, Xiaolin Tang, Liuquan Chang et al. · The Journal of Physical Chemistry B · 1999 · 336 citations

Mass and Heat Transfer in Vial Freeze-Drying of Pharmaceuticals: Role of the Vial

Michael J. Pikal, Michael L. Roy, Saroj Shah · Journal of Pharmaceutical Sciences · 1984 · 335 citations

Engineering, Desiccation, Pharmaceutical Technology +7

The collapse temperature in freeze drying: Dependence on measurement methodology and rate of water removal from the glassy phase

Michael J. Pikal, Saroj Shah · International Journal of Pharmaceutics · 1990 · 304 citations

Freeze-thaw Cycling, Ice-water System, Engineering +8