Michael J. Pikal

Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

Liuquan Chang, Deanna Shepherd, Joanna Sun et al. · Journal of Pharmaceutical Sciences · 2005 · 451 citations · Full text

Life Sciences, Biochemistry, Food Science +17

Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis

Sharad B. Murdande, Michael J. Pikal, Ravi Shanker et al. · Journal of Pharmaceutical Sciences · 2009 · 387 citations

Pharmacy, Pharmaceutics, Bioavailability +14

Mass and Heat Transfer in Vial Freeze-Drying of Pharmaceuticals: Role of the Vial

Michael J. Pikal, Michael L. Roy, Saroj Shah · Journal of Pharmaceutical Sciences · 1984 · 343 citations

Pharmacy, Food Science, Pharmaceutics +14

Characterization of the Time Scales of Molecular Motion in Pharmaceutically Important Glasses

Sheri L. Shamblin, Xiaolin Tang, Liuquan Chang et al. · The Journal of Physical Chemistry B · 1999 · 336 citations

Natural Sciences, Chemistry, Physics +16

The collapse temperature in freeze drying: Dependence on measurement methodology and rate of water removal from the glassy phase

Michael J. Pikal, Saroj Shah · International Journal of Pharmaceutics · 1990 · 305 citations

Pharmacy, Food Science, Food Preservation +13