Liuquan Chang

Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

Liuquan Chang, Deanna Shepherd, Joanna Sun et al. · Journal of Pharmaceutical Sciences · 2005 · 451 citations · Full text

Life Sciences, Biochemistry, Food Science +17

Characterization of the Time Scales of Molecular Motion in Pharmaceutically Important Glasses

Sheri L. Shamblin, Xiaolin Tang, Liuquan Chang et al. · The Journal of Physical Chemistry B · 1999 · 336 citations

Natural Sciences, Chemistry, Physics +16

Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state

Liuquan Chang, Deanna Shepherd, Joanna Sun et al. · Journal of Pharmaceutical Sciences · 2005 · 193 citations

Pharmacy, Biochemistry, Lyophilization +16

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions: Part 1. Unfolding, Colloidal Interactions, and Formation of High-Molecular-Weight Aggregates

Rebecca K. Brummitt, Douglas P. Nesta, Liuquan Chang et al. · Journal of Pharmaceutical Sciences · 2011 · 125 citations

Life Sciences, Biochemistry, Molecular Biology +17

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions, Part 2: Nucleation and Growth Kinetics with Competing Growth Mechanisms

Rebecca K. Brummitt, Douglas P. Nesta, Liuquan Chang et al. · Journal of Pharmaceutical Sciences · 2011 · 92 citations

Pharmacy, Biochemistry, Molecular Biology +16