Liuquan Chang

Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

Liuquan Chang, Deanna Shepherd, Joanna Sun et al. · Journal of Pharmaceutical Sciences · 2005 · 445 citations · Full text

Native Structure Preservation, Protein Chemistry, Biochemistry +8

Characterization of the Time Scales of Molecular Motion in Pharmaceutically Important Glasses

Sheri L. Shamblin, Xiaolin Tang, Liuquan Chang et al. · The Journal of Physical Chemistry B · 1999 · 336 citations

Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state

Liuquan Chang, Deanna Shepherd, Joanna Sun et al. · Journal of Pharmaceutical Sciences · 2005 · 190 citations

Protein Chemistry, Residual Moisture, Biochemistry +8

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions: Part 1. Unfolding, Colloidal Interactions, and Formation of High-Molecular-Weight Aggregates

Rebecca K. Brummitt, Douglas P. Nesta, Liuquan Chang et al. · Journal of Pharmaceutical Sciences · 2011 · 123 citations

Acidic Conditions, Protein Folding, Immunology +9

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions, Part 2: Nucleation and Growth Kinetics with Competing Growth Mechanisms

Rebecca K. Brummitt, Douglas P. Nesta, Liuquan Chang et al. · Journal of Pharmaceutical Sciences · 2011 · 92 citations

Immunocytochemical Technique, Acidic Conditions, Part 2 +10