KRIBB Repository · 2011 · 11 citations · 13 references
Life SciencesBiochemistryMicrobiologyMycologyOrganic ChemistryStructure-activity RelationshipsAntioxidant DefenseFungal BiochemistryFungal Secondary MetabolitesLipid PeroxidationMarine Bioactive CompoundsMarine Natural ProductsAntioxidant PropertiesAntioxidantsBioactive Compounds From Marine FungiBioactive Compounds From Marine SpongesFree Radical ScavengingMarine Fungal Natural ProductsMarine PolyketidesMarine-derived Antioxidants
A chemical investigation of the marine-derived fungi Aspergillus versicolor led to the isolation of a new aromatic polyketide (1), The structure was elucidated by spectroscopic analysis, and its radical-scavenging activity, reducing power, and inhibitory activity to lipid oxidation were investigated. Those activities of compound 1 were compared with standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tertiarybutylhydroquinone (TBHQ), and ascorbic acid (VC). Compound 1 showed antioxidant activity comparable to that of BHA, and siginificantly higher than that of BHT.
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