Concepedia

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki, Kazuyo Nakamura, Katsunori Takashima, Tsukasa Seya, Osamu Hazeki, Tomoyuki Kitazaki, Yuji Iizawa

Molecular Pharmacology · 2005 · 381 citations · 31 references

References

31

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

Life Sciences, Immunology, Microbiology +13

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan Medzhitov et al. · Nature · 2001 · 6.1K citations

Life Sciences, Immunology, Molecular Biology +14

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Samuel D. Wright, Robert Ramos, Peter S. Tobias et al. · Science · 1990 · 4K citations

Life Sciences, Biochemistry, Immunology +16

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.4K citations · Full text

Life Sciences, Immunology, Microbiology +13

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

Rintaro Shimazu, Sachiko Akashi, Hirotaka Ogata et al. · The Journal of Experimental Medicine · 1999 · 2.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +15