Osamu Hazeki

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Taro Okada, Y. Kawano, Tsuneki Sakakibara et al. · Journal of Biological Chemistry · 1994 · 918 citations · Full text

Insulin Receptor, Insulin Signaling, Molecular Pharmacology +19

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

Taro Okada, L. Sakuma, Yoshinori Fukui et al. · Journal of Biological Chemistry · 1994 · 437 citations · Full text

Pi 3-Kinase Activities, Immunology, Redox Biology +22

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki et al. · Molecular Pharmacology · 2005 · 363 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

Osamu Hazeki, M Ui · Journal of Biological Chemistry · 1981 · 330 citations · Full text

Receptor-mediated Regulation, Cardiac Muscle, Cardiovascular Function +16

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

Fumihiko Kanai, K. Ito, M. Todaka et al. · Biochemical and Biophysical Research Communications · 1993 · 282 citations

Pi3 Kinase, Molecular Physiology, Signal Transduction +13