Naoko Matsunaga

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Laura Riva, Shuofeng Yuan, Xin Yin et al. · Nature · 2020 · 856 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

Naoko Matsunaga, Noboru Tsuchimori, Tatsumi Matsumoto et al. · Molecular Pharmacology · 2010 · 593 citations

Life Sciences, Immunology, Molecular Biology +17

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki et al. · Molecular Pharmacology · 2005 · 381 citations

Life Sciences, Immunology, Pharmacology +17

Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model

Katsunori Takashima, Naoko Matsunaga, Mitsuhiro Yoshimatsu et al. · British Journal of Pharmacology · 2009 · 244 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Shuofeng Yuan, Xin Yin, Xiangzhi Meng et al. · Nature · 2021 · 211 citations · Full text

Medicine, Infectious Diseases, Pharmacology +17