Kaoru Hazeki

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki et al. · Molecular Pharmacology · 2005 · 381 citations

Life Sciences, Immunology, Pharmacology +17

Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis

Tomohiro Hirahashi, Misako Matsumoto, Kaoru Hazeki et al. · International Immunopharmacology · 2002 · 289 citations

Life Sciences, Immunology, Inflammation +16

Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model

Katsunori Takashima, Naoko Matsunaga, Mitsuhiro Yoshimatsu et al. · British Journal of Pharmacology · 2009 · 244 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

N. Ninomiya, Kaoru Hazeki, Yoshinori Fukui et al. · Journal of Biological Chemistry · 1994 · 211 citations · Full text

Life Sciences, Cell Biology, Immunology +11

The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

Satoshi Ota, Kaoru Hazeki, Navin Rao et al. · Journal of Biological Chemistry · 2000 · 90 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13