Masayuki Ii

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

Naoko Matsunaga, Noboru Tsuchimori, Tatsumi Matsumoto et al. · Molecular Pharmacology · 2010 · 567 citations

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

Todd W. Rice, Arthur P. Wheeler, Gordon R. Bernard et al. · Critical Care Medicine · 2010 · 479 citations

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki et al. · Molecular Pharmacology · 2005 · 363 citations

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

Tomohiro Kawamoto, Masayuki Ii, Tomoyuki Kitazaki et al. · European Journal of Pharmacology · 2008 · 314 citations

Inflammation, Toll-like Receptors, Intracellular Domain +13

Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model

Takukyu Sha, Mie Sunamoto, Tomoyuki Kitazaki et al. · European Journal of Pharmacology · 2007 · 175 citations

Inflammation, Toll-like Receptors, Cytokine +11