Tomoyuki Kitazaki

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki et al. · Molecular Pharmacology · 2005 · 381 citations

Life Sciences, Immunology, Pharmacology +17

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

Tomohiro Kawamoto, Masayuki Ii, Tomoyuki Kitazaki et al. · European Journal of Pharmacology · 2008 · 318 citations

Life Sciences, Immunology, Molecular Biology +14

Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model

Takukyu Sha, Mie Sunamoto, Tomoyuki Kitazaki et al. · European Journal of Pharmacology · 2007 · 176 citations

Life Sciences, Immunology, Pharmacology +17

Discovery of Novel and Potent Small-Molecule Inhibitors of NO and Cytokine Production as Antisepsis Agents:  Synthesis and Biological Activity of Alkyl 6-(N-Substituted sulfamoyl)cyclohex-1-ene-1-carboxylate

Masami Yamada, Takashi Ichikawa, Masayuki Ii et al. · Journal of Medicinal Chemistry · 2005 · 109 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3- <i>d</i> ]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Kazuhiro Miwa, Takenori Hitaka, Takashi Imada et al. · Journal of Medicinal Chemistry · 2011 · 100 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13