Takenori Hitaka

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Tomohiro Kaku, Takenori Hitaka, Akio Ojida et al. · Bioorganic & Medicinal Chemistry · 2011 · 126 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

Masuo Yamaoka, Takahito Hara, Takenori Hitaka et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 116 citations

Life Sciences, Endocrinology, Pharmacology +17

Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3- <i>d</i> ]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Kazuhiro Miwa, Takenori Hitaka, Takashi Imada et al. · Journal of Medicinal Chemistry · 2011 · 100 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Synthesis of queuine, the base of naturally occurring hypermodified nucleoside (queuosine), and its analogues

Hiroshi Akimoto, Eiko Imamiya, Takenori Hitaka et al. · Journal of the Chemical Society Perkin Transactions 1 · 1988 · 41 citations

Pharmacy, Biochemistry, Chemistry +17

Semisynthetic .beta.-lactam antibiotics. 6. Sulfocephalosporins and their antipseudomonal activities

Hiroaki Nomura, Takeshi Fugono, Takenori Hitaka et al. · Journal of Medicinal Chemistry · 1974 · 28 citations

Medicine, Medicinal Chemistry, Pharmacology +10