Concepedia

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Tomohiro Kaku, Takenori Hitaka, Akio Ojida, Nobuyuki Matsunaga, Mari Adachi, Toshimasa Tanaka, Takahito Hara, Masuo Yamaoka, Masami Kusaka, Teruaki Okuda,

Bioorganic & Medicinal Chemistry · 2011 · 126 citations · 59 references

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59

On enantiomorph-polarity estimation

H. D. Flack · Acta Crystallographica Section A Foundations of Crystallography · 1983 · 10.4K citations

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Mammalian Microsomal Cytochrome P450 Monooxygenase

Pamela A. Williams, José Cosme, Vandana Sridhar et al. · Molecular Cell · 2000 · 694 citations · Full text

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An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

William F. Greenlee, Alan Poland · Journal of Pharmacology and Experimental Therapeutics · 1978 · 624 citations

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p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol.

Lester A. Reinke, M J Moyer · Drug Metabolism and Disposition · 1985 · 416 citations

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Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic Cancer

Gerard A. Potter, S. Elaine Barrie, Michael Jarman et al. · Journal of Medicinal Chemistry · 1995 · 380 citations · Full text

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