Toshimasa Tanaka

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Kathleen Aertgeerts, R.J. Skene, Jason K. Yano et al. · Journal of Biological Chemistry · 2011 · 431 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami et al. · ACS Medicinal Chemistry Letters · 2010 · 247 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-<i>d</i>]pyrimidine Scaffold

Tomoyasu Ishikawa, Masaki Seto, Hiroshi Banno et al. · Journal of Medicinal Chemistry · 2011 · 216 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Conformational switch of angiotensin II type 1 receptor underlying mechanical stress‐induced activation

Noritaka Yasuda, Shin‐ichiro Miura, Hiroshi Akazawa et al. · EMBO Reports · 2008 · 180 citations · Full text

Natural Sciences, Biophysics, Physiology +14

Novel Inhibitor of p38 MAP Kinase as an Anti-TNF-α Drug:  Discovery of <i>N</i>-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a Potent and Orally Active Anti-Rheumatoid Arthritis Agent

Seiji Miwatashi, Yasuyoshi Arikawa, Etsuo Kotani et al. · Journal of Medicinal Chemistry · 2005 · 145 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17