Shinobu Sasaki

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami et al. · ACS Medicinal Chemistry Letters · 2010 · 247 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists

Shinobu Sasaki, Shuji Kitamura, Nobuyuki Negoro et al. · Journal of Medicinal Chemistry · 2011 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent

Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami et al. · Journal of Medicinal Chemistry · 2012 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonists

Nobuyuki Negoro, Shinobu Sasaki, Masahiro Ito et al. · Journal of Medicinal Chemistry · 2012 · 64 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Discovery of Phenylpropanoic Acid Derivatives Containing Polar Functionalities as Potent and Orally Bioavailable G Protein-Coupled Receptor 40 Agonists for the Treatment of Type 2 Diabetes

Satoshi Mikami, Shuji Kitamura, Nobuyuki Negoro et al. · Journal of Medicinal Chemistry · 2012 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15