Nobuyuki Negoro

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami et al. · ACS Medicinal Chemistry Letters · 2010 · 246 citations · Full text

Molecular Pharmacology, Pharmaceutical Science, Selective Gpr40 Agonist +12

TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats

Yoshiyuki Tsujihata, Ryo Ito, Masami Suzuki et al. · Journal of Pharmacology and Experimental Therapeutics · 2011 · 145 citations

Angiotensin Receptor-1 Blocker Inhibits Atherosclerotic Changes and Endothelial Disruption of the Aortic Valve in Hypercholesterolemic Rabbits

Kumiko Arishiro, Masaaki Hoshiga, Nobuyuki Negoro et al. · Journal of the American College of Cardiology · 2007 · 134 citations

Hypertension, Vascular Disease, Aortic Valve +10

Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists

Shinobu Sasaki, Shuji Kitamura, Nobuyuki Negoro et al. · Journal of Medicinal Chemistry · 2011 · 87 citations · Full text

Gpr40 Agonist Activity, Insulin Signaling, Metabolic Syndrome +16

Simple and Useful Tests for Discriminating Between Acute Aortic Dissection of the Ascending Aorta and Acute Myocardial Infarction in the Emergency Setting

Hiroshi Hazui, Hitoshi Fukumoto, Nobuyuki Negoro et al. · Circulation Journal · 2005 · 77 citations