Yoshiyuki Tsujihata - Concepedia

Concepedia

Author

Yoshiyuki Tsujihata

Also Known As

Tsujihata, Y., Tsujihata, Yoshiyuki, Y Tsujihata, YOSHIYUKI TSUJIHATA, Yoshiyuki Tsujihata, Yoshiyuki Tsujihata (469152)

29

Publications

1.3K

Citations

17

H-Index

41

Concepts

All Affiliations

YT

About

Yoshiyuki Tsujihata is an author at Takeda (Japan) specializing in medicine, pharmacology, and biochemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	9	9	755
2	Biochemistry	7	7	570
3	Natural Sciences	4	4	187
4	Health Sciences	2	2	94
5	Biomolecular Engineering	1	1	73

Yoshiyuki Tsujihata

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18

Publications

1.3K

Citations

17

H-Index

	Year	Citations
Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami, ACS Medicinal Chemistry Letters Molecular PharmacologyPharmaceutical ScienceSelective Gpr40 AgonistBiochemistryFunctional Selectivity	2010	246
Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration Hiroyuki Katayama, Hiroshi Hama, Koji Nagasawa, Cell Cell AutophagyMitophagyNeurodegenerative DiseasesMedicineAutophagy	2020	164
TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats Yoshiyuki Tsujihata, Ryo Ito, Masami Suzuki, Journal of Pharmacology and Experimental Therapeutics	2011	145
A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1 Chiori Yabuki, Hidetoshi Komatsu, Yoshiyuki Tsujihata, PLoS ONE	2013	91
Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists Shinobu Sasaki, Shuji Kitamura, Nobuyuki Negoro, Journal of Medicinal Chemistry Gpr40 Agonist ActivityInsulin SignalingMetabolic SyndromeMolecular PharmacologyMetabolic Signaling	2011	87
The Effects of TAK-875, a Selective G Protein-Coupled Receptor 40/Free Fatty Acid 1 Agonist, on Insulin and Glucagon Secretion in Isolated Rat and Human Islets Hiroaki Yashiro, Yoshiyuki Tsujihata, Koji Takeuchi, Journal of Pharmacology and Experimental Therapeutics	2011	85
Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami, Journal of Medicinal Chemistry GlycobiologyInsulin SignalingMetabolic SyndromeMedicinal ChemistryMolecular Pharmacology	2012	73
Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonists Nobuyuki Negoro, Shinobu Sasaki, Masahiro Ito, Journal of Medicinal Chemistry Peptide SciencePharmacotherapyInsulin SignalingImproved Pharmacokinetic ProfilesMolecular Pharmacology	2012	64
Discovery of Phenylpropanoic Acid Derivatives Containing Polar Functionalities as Potent and Orally Bioavailable G Protein-Coupled Receptor 40 Agonists for the Treatment of Type 2 Diabetes Satoshi Mikami, Shuji Kitamura, Nobuyuki Negoro, Journal of Medicinal Chemistry Pharmaceutical SciencePharmacotherapyPolar SubstituentsPharmaceutical ChemistryMedicinal Chemistry	2012	52
<scp>TAK</scp>‐875, a <scp>GPR</scp>40/<scp>FFAR</scp>1 agonist, in combination with metformin prevents progression of diabetes and <scp>β</scp>‐cell dysfunction in <scp>Z</scp>ucker diabetic fatty rats Ryo Ito, Yoshiyuki Tsujihata, Matsuda-Nagasumi Kae, British Journal of Pharmacology	2013	36

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