1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438), a Novel and Potent Potassium-Competitive Acid Blocker for the Treatment of Acid-Related Diseases

Yasunobu Hori, Akio Imanishi, Jun Matsukawa, +6

Journal of Pharmacology and Experimental Therapeutics

Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1<i>H</i>-pyrrol-3-yl]-<i>N</i>-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)

Yasuyoshi Arikawa, Haruyuki Nishida, Osamu Kurasawa, +12

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPotassium-competitive Acid BlockerPyrrole DerivativesCompound 13E +15

Novel Inhibitor of p38 MAP Kinase as an Anti-TNF-α Drug:  Discovery of <i>N</i>-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a Potent and Orally Active Anti-Rheumatoid Arthritis Agent

Seiji Miwatashi, Yasuyoshi Arikawa, Etsuo Kotani, +6

Journal of Medicinal Chemistry

Novel InhibitorP38 Map KinaseImmunologyCell DeathP38 Mitogen-activated Protein +21

Enantioselective <i>ortho</i>-Lithiation of Substituted Ferrocenes

Yoshiaki Nishibayashi, Yasuyoshi Arikawa, Kouichi Ohe, +1

The Journal of Organic Chemistry

Asymmetric CatalysisChemical EngineeringDerivative (Chemistry)EngineeringDonut Icon +8

Iridium-Catalyzed Asymmetric Hydrosilylation of Imines Using Chiral Oxazolinyl-Phosphine Ligands

Izuru Takei, Yoshiaki Nishibayashi, Yasuyoshi Arikawa, +2

Organometallics

Enantioselective SynthesisEngineeringChiral OxazolinylphosphinesAsymmetric HydrosilylationOrganic Chemistry +6

Synthesis and structure of novel chiral oxazolinylferrocenes and oxazolinylferrocenylphosphines, and their rhodium(I)-complexes

Yoshiaki Nishibayashi, Kyohei Segawa, Yasuyoshi Arikawa, +3

Journal of Organometallic Chemistry

Novel Chiral OxazolinylferrocenesCoordination ComplexOrganic ChemistryMolecular ComplexChemistry +1

Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)

Betty Lam, Yasuyoshi Arikawa, Joshua Cramlett, +19

Bioorganic & Medicinal Chemistry Letters

BiochemistryAvailable Investigational InhibitorMedicineReceptor Tyrosine KinaseImmunology +5

Rhodium(I)-, iridium(I)-, and ruthenium(II)-catalyzed asymmetric transfer hydrogenation of ketones using diferrocenyl dichalcogenides as chiral ligands

Yoshiaki Nishibayashi, Jai Deo Singh, Yasuyoshi Arikawa, +2

Journal of Organometallic Chemistry

Inorganic ChemistryChemical EngineeringAsymmetric Transfer HydrogenationChiral LigandsEngineering +6

Ruthenium(II)-catalyzed asymmetric transfer hydrogenation of ketones using chiral oxazolinylferrocenylphosphines and one of their Ru(II) complex

Yasuyoshi Arikawa, Masanao Ueoka, Kazutaka Matoba, +3

Journal of Organometallic Chemistry

Inorganic ChemistryChemical EngineeringAsymmetric Transfer HydrogenationEngineeringOrganometallic Catalysis +5

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers

Haruyuki Nishida, Atsushi Hasuoka, Yasuyoshi Arikawa, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryNatural SciencesMedicineNovel Pyrrole Derivatives +7