Akio Imanishi

1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438), a Novel and Potent Potassium-Competitive Acid Blocker for the Treatment of Acid-Related Diseases

Yasunobu Hori, Akio Imanishi, Jun Matsukawa et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 202 citations

Medicine, Pharmacology, Pharmacotherapy +12

Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1<i>H</i>-pyrrol-3-yl]-<i>N</i>-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)

Yasuyoshi Arikawa, Haruyuki Nishida, Osamu Kurasawa et al. · Journal of Medicinal Chemistry · 2012 · 157 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers

Haruyuki Nishida, Atsushi Hasuoka, Yasuyoshi Arikawa et al. · Bioorganic & Medicinal Chemistry · 2012 · 46 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Piyush Bajaj, Git Chung, Keith Pye et al. · Toxicology · 2020 · 34 citations

Medicine, Cell Biology, Nephrology +13

Bidirectional Regulation of Human Colonic Smooth Muscle Contractility by Tachykinin NK2 Receptors

Akihiro Nakamura, Takahiro Tanaka, Akio Imanishi et al. · Journal of Pharmacological Sciences · 2011 · 23 citations · Full text

Life Sciences, Pharmacology, Physiology +11