Etsuo Kotani

Novel Inhibitor of p38 MAP Kinase as an Anti-TNF-α Drug:  Discovery of <i>N</i>-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a Potent and Orally Active Anti-Rheumatoid Arthritis Agent

Seiji Miwatashi, Yasuyoshi Arikawa, Etsuo Kotani et al. · Journal of Medicinal Chemistry · 2005 · 145 citations · Full text

Novel Inhibitor, P38 Map Kinase, Immunology +23

Synthesis of pyrazolo[1,5-a]pyridines by thermal intramolecular cyclization

Yasutaka Hoashi, Takafumi Takai, Etsuo Kotani et al. · Tetrahedron Letters · 2013 · 18 citations

Heterocyclic, Thermal Intramolecular Cyclization, Organic Chemistry +2

Discovery of Novel and Potent Orally Active Calcium-Sensing Receptor Antagonists that Stimulate Pulselike Parathyroid Hormone Secretion: Synthesis and Structure−Activity Relationships of Tetrahydropyrazolopyrimidine Derivatives

Masato Yoshida, Akira Mori, Etsuo Kotani et al. · Journal of Medicinal Chemistry · 2011 · 13 citations · Full text

Medicinal Chemistry, Biochemistry, Functional Selectivity +14

Novel and potent calcium-sensing receptor antagonists: Discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent

Masato Yoshida, Akira Mori, Shinji Morimoto et al. · Bioorganic & Medicinal Chemistry · 2011 · 11 citations · Full text

Medicinal Chemistry, Medicine, Pharmacological Agent +7