Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.

Takahito Hara, Jun‐ichi Miyazaki, Hideo Araki, +4

PubMed

Molecular PharmacologyAndrogen ReceptorUrologyRefractory PcBicalutamide Withdrawal Syndrome +10

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

Masami Kusaka, Katsuichi Sudo, Takeshi Fujita, +4

Biochemical and Biophysical Research Communications

InflammationAntifungal AgentAngiogenesisMedicinePathology +4

Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470)

Masami Kusaka, K Sudo, Etsuya Matsutani, +5

British Journal of Cancer

AngiogenesisEndothelial Cell GrowthMedicineAngiogenesis Inhibitor Tnp-470Cytostatic Inhibition +8

Stimulation of prostaglandin E2 synthesis in cloned osteoblastic cells of mouse (MC3T3-E1) by epidermal growth factor.

Kazushige Yokota, Masami Kusaka, Takehiro Ohshima, +4

Journal of Biological Chemistry

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Tomohiro Kaku, Takenori Hitaka, Akio Ojida, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistrySelective 17,20-Lyase InhibitorPotential UtilityMedicinePharmacotherapy +7

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

Masuo Yamaoka, Takahito Hara, Takenori Hitaka, +7

The Journal of Steroid Biochemistry and Molecular Biology

Steroid SynthesisMedicinal ChemistryAdrenal GlandCynomolgus MonkeysEndocrine Mechanism +8

Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3- <i>d</i> ]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Kazuhiro Miwa, Takenori Hitaka, Takashi Imada, +9

Journal of Medicinal Chemistry

AGM-1470, a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle.

Nadine Antoine, Roland Greimers, C. De Roanne, +4

PubMed

Endothelial CellsPathologyCell CycleCancer BiologyTumor Biology +16

Suppression of the hypothalamic–pituitary–gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: Studies in human GnRH receptor knock-in mice

Daisuke Nakata, Tsuneo Masaki, Akira Tanaka, +8

European Journal of Pharmacology

Endocrine MechanismMedicineHormonal ReceptorPhysiologyUterine Receptivity +9

Chronic Administration of the Metastin/Kisspeptin Analog KISS1-305 or the Investigational Agent TAK-448 Suppresses Hypothalamic Pituitary Gonadal Function and Depletes Plasma Testosterone in Adult Male Rats

Hisanori Matsui, Akira Tanaka, Kotaro Yokoyama, +10

Endocrinology

Chronic AdministrationKisspeptin AnalogsReproductive BiologySocial SciencesReproductive Endocrinology +17