Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

Donald E. Ingber, Takeshi Fujita, SHOJI KISHIMOTO, +4

Nature

Inhibit AngiogenesisAngiogenesisAntifungal AgentTumour GrowthMedicine +7

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

Masami Kusaka, Katsuichi Sudo, Takeshi Fujita, +4

Biochemical and Biophysical Research Communications

InflammationAntifungal AgentAngiogenesisMedicinePathology +4

Reduction of Insulin Resistance in Obese and/or Diabetic Animals by 5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a New Antidiabetic Agent

Takeshi Fujita, Yasuo Sugiyama, Shigehisa Taketomi, +4

Diabetes

Diabetic AnimalsMetabolic DisorderNew Antidiabetic AgentInsulin SignalingObesity +18

Studies on antidiabetic agents. II. Synthesis of 5-(4-(1-methylcyclohexylmethoxy)-benzyl)thiazolidine-2,4-dione (ADD-3878) and its derivatives.

Takashi Sohda, Katsutoshi Mizuno, Eiko Imamiya, +3

Chemical and Pharmaceutical Bulletin

Derivative (Chemistry)Medicinal ChemistryPharmaceutical ScienceBioorganic ChemistryDerivatives +13

Stimulatory effects of substance P and nerve growth factor (NGF) on neurite outgrowth in embryonic chick dorsal root ganglia

Narumi Shigehiko, Takeshi Fujita

Neuropharmacology

NeuroregenerationDevelopmental BiologyPhysiologyNerve Growth FactorNeurogenesis +8

Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents

Takashi Sohda, Katsutoshi Mizuno, Yū Momose, +3

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyAntidiabetic AgentsPharmaceutical ChemistryMedicinal Chemistry +14

Stimulation of the respiratory and phosphorylating activities in rat brain mitochondria by idebenone (CV‐2619), a new agent improving cerebral metabolism

Yasuo Sugiyama, Takeshi Fujita

FEBS Letters

Cerebral MetabolismLipid PeroxidationNon-respiratory Oxygen ConsumptionMitochondrial BiologyRedox Biology +22

Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs.

Yasuo Sugiyama, Takeshi Fujita, Mutsuko Matsumoto, +2

Journal of Pharmacobio-Dynamics

Biotransformation of Molsidomine (<i>N</i>-Ethoxycarbonyl-3-morpholinosydnonimine), a New Anti-anginal Agent, in Rats

Shigeharu Tanayama, Yoichi Nakai, Takeshi Fujita, +3

Xenobiotica

Blood Molsidomine LevelPharmacotherapyExperimental PharmacologyPharmaceutical ChemistryNew Anti-anginal Agent +16

Effects of idebenone and related compounds on respiratory activities of brain mitochondria, and on lipid peroxidation of their membranes

Isuke Imada, Takeshi Fujita, Yasuo Sugiyama, +2

Archives of Gerontology and Geriatrics

BiochemistryMitochondrial FunctionMedicineLipid PeroxidationPhysiology +8