Reduction of Insulin Resistance in Obese and/or Diabetic Animals by 5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a New Antidiabetic Agent

Takeshi Fujita, Yasuo Sugiyama, Shigehisa Taketomi, +4

Diabetes

Diabetic AnimalsMetabolic DisorderNew Antidiabetic AgentInsulin SignalingObesity +18

Potent Ectopic Bone-Inducing Activity of Bone Morphogenetic Protein-4/7 Heterodimer

Aki Aono, Masaaki Hazama, Kohei Notoya, +5

Biochemical and Biophysical Research Communications

Developmental BiologyBone Morphogenic ProteinBone HomeostasisMedicineCell Biology +3

<i>In Vivo</i>Stimulation of Endosteal Bone Formation by Basic Fibroblast Growth Factor in Rats

Hiroshi Mayahara, Takayasu Ito, Hirofumi Nagai, +5

Growth Factors

EngineeringEndosteal Bone FormationIntravenous AdministrationBone RepairOsteoporosis +15

Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles.

T Miyata, Kohei Notoya, Kentaroh Yoshida, +4

Journal of the American Society of Nephrology

Tissue EngineeringEngineeringBone ResorptionAccelerated Bone ResorptionGlycobiology +18

Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

Kae Nagasumi, Ritsuko Esaki, Kimihiko Iwachidow, +10

Diabetes

Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.

Hitoshi Ikeda, Shigehisa Taketomi, Yuichiro Sugiyama, +4

PubMed

PharmacotherapyExperimental PharmacologyInsulin SignalingMetabolic SyndromeObese Beagle Dogs +15

Studies on Disease-Modifying Antirheumatic Drugs:  Synthesis of Novel Quinoline and Quinazoline Derivatives and Their Anti-inflammatory Effect

Atsuo Baba, Noriaki Kawamura, Haruhiko Makino, +3

Journal of Medicinal Chemistry

Novel QuinolineAa Rat ModelAntiparasitic AgentImmunologyPharmacotherapy +15

Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent

T. Fujita, Yukiteru Sugiyama, Shigehisa Taketomi, +4

Diabetes

Insulin ResistanceMetabolic SyndromeDiabetes ManagementBiochemistryMedicine +9

Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats.

Yuichiro Sugiyama, Shigehisa Taketomi, Yukia Shimura, +2

PubMed

ObesityMetabolic SyndromeInsulin ResistanceGlucose ToleranceSevere Insulin Resistance +13

Characterization of transgenic rats constitutively expressing vitamin D-24-hydroxylase gene

Hisao Kasuga, Naobumi Hosogane, Kunio Matsuoka, +6

Biochemical and Biophysical Research Communications

Knockout MouseTransgenic RatsGeneticsBiochemical GeneticsMetabolism +2