An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

Hideki Kizawa, Ikuyo Kou, Aritoshi Iida, +12

Nature Genetics

InflammationAnti-inflammatoryMusculoskeletal ResearchAsporin Inhibits ChondrogenesisCartilage Degeneration +4

The Induction of Cell Death in Human Osteoarthritis Chondrocytes by Nitric Oxide Is Related to the Production of Prostaglandin E2 Via the Induction of Cyclooxygenase-2

Kohei Notoya, Dragan Jovanović, Pascal Reboul, +3

The Journal of Immunology

Pge2 ProductionPge2 ReleaseLipid PeroxidationApoptosisCell Death +21

Potent Ectopic Bone-Inducing Activity of Bone Morphogenetic Protein-4/7 Heterodimer

Aki Aono, Masaaki Hazama, Kohei Notoya, +5

Biochemical and Biophysical Research Communications

Developmental BiologyBone Morphogenic ProteinBone HomeostasisMedicineCell Biology +3

Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles.

T Miyata, Kohei Notoya, Kentaroh Yoshida, +4

Journal of the American Society of Nephrology

Tissue EngineeringEngineeringBone ResorptionAccelerated Bone ResorptionGlycobiology +18

A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese

Hideyuki Mototani, Akihiko Mabuchi, Susumu Saito, +12

Human Molecular Genetics

Hip OsteoarthritisGeneticsGenetic EpidemiologyHuman PolymorphismPathology +15

Parathyroid Hormone-activated Volume-sensitive Calcium Influx Pathways in Mechanically Loaded Osteocytes

Akimitsu Miyauchi, Kohei Notoya, Yuko Mikuni‐Takagaki, +9

Journal of Biological Chemistry

Stretch LoadingEngineeringMean Cell VolumeBiomedical EngineeringMechanically Loaded Osteocytes +18

Pioglitazone, a peroxisome proliferator–activated receptor γ agonist, reduces the progression of experimental osteoarthritis in guinea pigs

Tetsuya Kobayashi, Kohei Notoya, Takako Naito, +4

Arthritis & Rheumatism

αVβ3 Integrin ligands enhance volume-sensitive calcium influx in mechanically stretched osteocytes

Akimitsu Miyauchi, Masayuki Gotoh, Hiroshi Kamioka, +9

Journal of Bone and Mineral Metabolism

MechanobiologyEngineeringBiomechanicsBone HomeostasisBiomedical Engineering +9

Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation.

Dragan Jovanović, François Mineau, Kohei Notoya, +3

PubMed

Effect of ipriflavone on expression of markers characteristic of the osteoblast phenotype in rat bone marrow stromal cell culture

Kohei Notoya, Keiji Yoshida, Ryoichi Tsukuda, +1

Journal of Bone and Mineral Research

Regenerative MedicineInflammationOsteoblast PhenotypeOrthopaedic SurgeryBone Morphogenic Protein +13