José Cosme

Crystal structure of human cytochrome P450 2C9 with bound warfarin

Pamela A. Williams, José Cosme, Alison Ward et al. · Nature · 2003 · 812 citations

Molecular Pharmacology, Crystal Structure, Biochemistry +9

Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone

Pamela A. Williams, José Cosme, Dijana Matak‐Vinković et al. · Science · 2004 · 804 citations

Drug Target, Aldo-keto Reductase, Molecular Biology +16

Mammalian Microsomal Cytochrome P450 Monooxygenase

Pamela A. Williams, José Cosme, Vandana Sridhar et al. · Molecular Cell · 2000 · 689 citations · Full text

Biochemistry, Medicine, Biochemical Genetics +6

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Andrew Woodhead, Hayley C. Angove, Maria G. Carr et al. · Journal of Medicinal Chemistry · 2010 · 258 citations

Pharmaceutical Science, Novel Inhibitor, Drug Target +19

Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*

Georg Engel, Ute Hofmann, H. Heidemann et al. · Clinical Pharmacology & Therapeutics · 1996 · 173 citations