Alan Poland

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

Alan Poland, Edward Glover, Andrew S. Kende · Journal of Biological Chemistry · 1976 · 1.4K citations · Full text

High Affinity Binding, Chemical Biology, Toxicological Mechanism +18

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

K.M. Burbach, Alan Poland, Christopher A. Bradfield · Proceedings of the National Academy of Sciences · 1992 · 835 citations · Full text

Molecular Regulation, Genetics, Molecular Biology +17

An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

William F. Greenlee, Alan Poland · Journal of Pharmacology and Experimental Therapeutics · 1978 · 624 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

Alan Poland, Edward Glover · PubMed · 1980 · 393 citations

Allergy, Biochemistry, Medicine +15

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

Henry C. Pitot, Thomas L. Goldsworthy, Harold A. Campbell et al. · PubMed · 1980 · 373 citations

Pathology, Toxicological Mechanism, Single Initiating Dose +18