Katsunori Takashima

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki et al. · Molecular Pharmacology · 2005 · 381 citations

Life Sciences, Immunology, Pharmacology +17

Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model

Katsunori Takashima, Naoko Matsunaga, Mitsuhiro Yoshimatsu et al. · British Journal of Pharmacology · 2009 · 244 citations · Full text

Life Sciences, Immunology, Pharmacology +17

TAK-652 Inhibits CCR5-Mediated Human Immunodeficiency Virus Type 1 Infection In Vitro and Has Favorable Pharmacokinetics in Humans

Masanori Baba, Katsunori Takashima, Hiroshi Miyake et al. · Antimicrobial Agents and Chemotherapy · 2005 · 109 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Highly Potent and Orally Active CCR5 Antagonists as Anti-HIV-1 Agents:  Synthesis and Biological Activities of 1-Benzazocine Derivatives Containing a Sulfoxide Moiety

Masaki Seto, Katsuji Aikawa, Naoki Miyamoto et al. · Journal of Medicinal Chemistry · 2006 · 89 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Isolation and Characterization of Human Immunodeficiency Virus Type 1 Resistant to the Small-Molecule CCR5 Antagonist TAK-652

Masanori Baba, Hiroshi Miyake, Xin Wang et al. · Antimicrobial Agents and Chemotherapy · 2006 · 86 citations · Full text

Life Sciences, Infectious Diseases, Pharmacology +15