Yuji Iizawa

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

Masanori Baba, Osamu Nishimura, Naoyuki Kanzaki et al. · Proceedings of the National Academy of Sciences · 1999 · 755 citations · Full text

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki et al. · Molecular Pharmacology · 2005 · 363 citations

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

Tomohiro Kawamoto, Masayuki Ii, Tomoyuki Kitazaki et al. · European Journal of Pharmacology · 2008 · 314 citations

Inflammation, Toll-like Receptors, Intracellular Domain +13

Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model

Katsunori Takashima, Naoko Matsunaga, Mitsuhiro Yoshimatsu et al. · British Journal of Pharmacology · 2009 · 240 citations · Full text

Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice

Koji Takashima, Kazuhiro Tateda, Tetsuya Matsumoto et al. · Infection and Immunity · 1997 · 177 citations · Full text

Inflammatory Lung Disease, Lung Inflammation, Humoral Response +18