Concepedia

An antiaggregation gene therapy strategy for Lewy body disease utilizing β-synuclein lentivirus in a transgenic model

Makoto Hashimoto, Edward Rockenstein, Michael Mante, Leslie Crews, Pazit Bar‐On, F H Gage, Robert A. Marr, Eliezer Masliah

Gene Therapy · 2004 · 85 citations · 38 references

DOI

Concepts

References

38

High-Level Neuronal Expression of Aβ<sub>1–42</sub>in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Lennart Mucke, Eliezer Masliah, Gui-Qiu Yu et al. · Journal of Neuroscience · 2000 · 1.9K citations · Full text

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Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Eliezer Masliah, Edward Rockenstein, Isaac Veinbergs et al. · Science · 2000 · 1.8K citations

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Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

W. Sean Davidson, Ana Jonas, David F. Clayton et al. · Journal of Biological Chemistry · 1998 · 1.6K citations · Full text

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Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Kelly A. Conway, Seung‐Jae Lee, Jean‐Christophe Rochet et al. · Proceedings of the National Academy of Sciences · 2000 · 1.5K citations

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Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

Kelly A. Conway, James D. Harper, Peter T. Lansbury · Nature Medicine · 1998 · 1.5K citations

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