Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini, +31

Nature

Alzheimer-type NeuropathologyNeurodegenerative DiseasesAlzheimer's DiseaseMolecular NeuroscienceTransgenic Mouse Models +10

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Erik D. Roberson, Kimberly Scearce‐Levie, Jorge J. Palop, +5

Science

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Lennart Mucke, Eliezer Masliah, Gui-Qiu Yu, +7

Journal of Neuroscience

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseAmyloid PlaquesDementia +13

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Eliezer Masliah, Edward Rockenstein, Isaac Veinbergs, +6

Science

Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease

Jorge J. Palop, Jeannie Chin, Erik D. Roberson, +10

Neuron

Compensatory RemodelingAlzheimer's DiseaseBrain FunctionMedicineDementia +9

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

Laure Verret, Edward O. Mann, Giao B. Hang, +9

Cell

Alzheimer ModelNeuropsychologyAlzheimer's DiseaseCognitive ScienceBrain Function +9

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Albert Y. Hsia, Eliezer Masliah, Lisa McConlogue, +7

Proceedings of the National Academy of Sciences

Synaptic TransmissionNeurochemical BiomarkersAmyloid Beta PeptideNeuroinflammationAlzheimer's Disease +14

Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

Toby G. Bush, Narman Puvanachandra, Catherine H. Horner, +6

Neuron

Reactive AstrocytesNeuroregenerationMedicineImmunologyAdult Transgenic Mice +6

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

Iain L. Campbell, Carmela R. Abraham, Eliezer Masliah, +4

Proceedings of the National Academy of Sciences

ImmunologyCell DeathTransgenic MiceSocial SciencesNeuroinflammation +17

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Jennifer Chen, Yungui Zhou, Sarah Mueller-Steiner, +5

Journal of Biological Chemistry

ImmunologyImmune RegulationCell DeathOxidative StressNeuroinflammation +17